Regulation of fuel selection by adropin
نویسندگان
چکیده
1 Department of Metabolism and Aging, Scripps Research Institute, Jupiter, FL, USA. 2 Department of Human Nutrition, Foods and Exercise; Virginia Polytechnic Institute and State University, Blacksburg VA, USA 3 Basic Sciences Department, Faculty of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain 4 Department of Biochemistry and Molecular Biology and Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición, Facultat de Farmàcia, Universitat de Barcelona, E-08028 Barcelona, Spain 5 Department of Pediatrics, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. 6 Department of Pharmacological & Physiological Science, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, USA
منابع مشابه
Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance
OBJECTIVE The peptide hormone adropin regulates fuel selection preferences in skeletal muscle under fed and fasted conditions. Here, we investigated whether adropin treatment can ameliorate the dysregulation of fuel substrate metabolism, and improve aspects of glucose homeostasis in diet-induced obesity (DIO) with insulin resistance. METHODS DIO C57BL/6 mice maintained on a 60% kcal fat diet ...
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Rigorous control of substrate oxidation by humoral factors is essential for maintaining metabolic homeostasis. During feeding and fasting cycles, carbohydrates and fatty acids are the two primary substrates in oxidative metabolism. Here, we report a novel role for the peptide hormone adropin in regulating substrate oxidation preferences. Plasma levels of adropin increase with feeding and decrea...
متن کاملAdropin acts in the rat paraventricular nucleus to influence neuronal excitability.
Adropin is a peptide hormone with cardiovascular and metabolic roles in the periphery, including effects on glucose and lipid homeostasis. Central administration of adropin has been shown to inhibit water intake in rats; however, the site at which central adropin acts has yet to be elucidated. The hypothalamic paraventricular nucleus (PVN), a critical autonomic control center, plays essential r...
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BACKGROUND Adropin is a recently identified protein that has been implicated in the maintenance of energy homeostasis and insulin resistance. Because vascular function and insulin sensitivity are closely related, we hypothesized that adropin may also exert direct effects on the endothelium. METHODS AND RESULTS In vitro cell culture models were partnered with an in vivo murine injury model to ...
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